First reaction, probably not complete. The positive has been said already, now for what is broken.
Lock Target does not capture every creature within your field of vision. Sometimes it seems to only work along a narrow line through the center, sometimes a bit further to the side. Haven't quite figured out yet what it depends on. But more often than not, with creatures clearly visible, whether in 3rd or 1st person view, it doesn't seem to work as expected.
When a creature drops dead, especially a flying one falling to the ground, the target lock seems to be released. If I'm not very quick, the interaction button does not loot it but either has the next target selected already or opens a useless context menu. I then have to interrupt my pattern and use the mouse to turn and find the carcass again to loot it. Very annoying.
Sorely missed is a way to go backwards through the target sequence or to start over as the removed functions "select previous target" and "unselect target" provided.
Can't target flying creatures using the keyboard only with the functions look up/down removed.
It is not very often that I play sitting upright like a good boy at the dining table or an office worker, with one hand on the keyboard and one on the mouse. Suggestion: Take the furniture out of one room in the office, throw a few mattresses, make a mess of blankets and cushions and toys and food and whatever, add some real distractions (if employees have pre-school children let them come along and be right there with you) to expose your devs to some real-life conditions. This will help them create a product which works for everybody. Cheers!