First impressions from me after a few hours last night hunting and messing around in towns - once I got used to the basic controls I started to quite like it, though it'll definitely take a while to undo my muscle memory from 13 years of hunting in more or less the same way, and to work out the best key mappings for me to use (I prefer to use the mouse as little as possible).
There are certainly improvements that can be made, and my priorities would be those that have already been repeatedly brought up here, especially by experienced and active hunters, namely:
1. Camera movement when the mob is moving towards me is very annoying and often leaves me facing at a bad angle when I've finished the mob, forcing me to readjust (which I can only do with mouse).
2. Target cycling definitely needs to be more like the old system. At the moment it mainly seems to just alternate between two mobs most of the time. Another vote for always picking the closest one whether it's on-screen or not.
3. Zooming further out would definitely be better, though I don't find this as problematic as some seem to.
A couple of things that haven't been mentioned so much:
4. Sometimes the camera zoom was bouncing in and out all the time, which was very annoying. Mainly this was happening in Cyrene service centres, so it's probably more of a problem with their design than with the system (it's always been a bad design even without this).
5. This one that Xen mentioned:
move left/move right makes a vehicle *rotate* left/right
rotate left/rotate right makes a vehicle move/strafe left/right
This is backwards.
edit: I mean flying vehicles ofc
I don't think this has actually changed, but now I'm using the keys much more than previously for avatar movement, which has made the discrepancy between the two much more difficult to deal with.
As usual the best way to address these problems would be not to change things entirely, but to give us more options for controlling how we want the game to behave.